Jefferson Regional Foundation, based in Pittsburgh, PA, is a dedicated grantmaking organization that focuses on improving the health and vitality of the communities served by Jefferson Hospital. Since its inception in March 2013, the Foundation has awarded over $17 million in grants to 120 different community organizations in the South Hills and Mon Valley areas. The Foundation operates three major grant cycles each year and also offers minigrants, all with a strong emphasis on addressing the social determinants of health.

Their priorities include promoting health and wellness, fostering diversity, equity, and inclusion, supporting workforce and economic opportunity, driving civic engagement and policy work, and investing in early childhood and youth development. They also prioritize capacity building within community-serving organizations. One of the Foundation's key initiatives is the Jefferson Forum, an annual community learning event that brings together stakeholders to share information and foster partnerships.

The Foundation also actively participates in the Jefferson Community Collaborative, a network of over 100 organizations that work together to incubate innovative ideas, improve organizational capacity, and take collective action on community goals. In addition, the Foundation is committed to providing local data and resources to the community. They have published Community Snapshots and host the Jefferson Directory, a resource guide that facilitates referrals and connections among organizations serving local residents.

With their dedication to community engagement, collaboration, and addressing social determinants of health, Jefferson Regional Foundation plays a vital role in enhancing the well-being of Pittsburgh's South Hills and Mon Valley areas