The Thunderbird Partnership Foundation is a non-profit organization dedicated to collaborating with First Nations communities to tackle substance use and addiction. They prioritize a holistic approach to healing and wellness that emphasizes culture, respect, community, and compassion. As a national voice in advocating for First Nations culturally-based addiction services, their mission is to cultivate and empower relationships that promote integrated and holistic approaches to healing and wellness.

The foundation operates within core frameworks such as the First Nations Mental Wellness Continuum Framework, Indigenous Wellness Framework, and Honouring Our Strengths Framework. Their guiding principles include prioritizing clients' interests, promoting client initiative, supporting harm reduction strategies, ensuring accountability and transparency, and working through partnerships. By continuously evaluating and adapting program methodologies, the Thunderbird Partnership Foundation aims to provide demonstrably effective prevention and intervention methodologies, delivered by knowledgeable and skilled workers.

With values such as respect, honesty, compassion, and trust, the foundation strives to create wholistic approaches that acknowledge the interconnectedness of causes, consequences, and solutions