At Oroxcell, we are actively committed to bringing top level partnership and services to biotech / pharmaceutical, cosmetic, food, veterinary and home products / Contract Research Organisation/ Société de Recherche Contractuelle / Food health / Alternative methods to animal use/ veterinary / vétérinaire / bioavailability / REACH/ ECHA / in vitro / in vitro toxicity / toxicité / Cellular Absorption / Liver / Hepatic / Hepatic Metabolism / Drug-Drug Interactions / DDI / hepatic DDIs / hepatic DILIs / liver DDIs / DiLis/ CYP 450 and UGT phenotyping / CYP450 induction / Uptake and Efflux transporter inhibition / Bile Salt Export Pump (BSEP) inhibition / Inhibition de la pompe d’exportation de sel biliaires / Drug Drug interactions / Liver / Foi / Intestinal / intestins / renal / reins / FDA Compliance / PK parameters pharmaco-kinetic/ QA / Quality insurance/ Assurance qualité / nutrition health /Nutrition Santé / Skin irritation / irritation cutanée / Irritation oculaire / Occular irritation / CRO / Caco 2 TC7 cells / ready to use plated caco-2 TC7 cells/ 24 or 96 well plates for Caco-2 TC7 cells / BCS Biowaiwer / Generics / Correlation curve / Courbe de corrélation / toxicology /safety assessment / efficacy / ADME / benefit risk / alternative methods to animal use/ safety evaluation / regulatory / GLP compliance study / studies / in-chemico / bio analyses / GLP / good laboratory practices / preclinical studies / ingredients / complex mixtures / microbiota extract / finished products / AOP/ IATA / botanical extracts / formulations / raw materials / extracts / cosmetic / dermo-cosmetic / dermatology / nutrition / pharmaceutic / chemical / medical device / biotechnology / RHE / RHE micronucleus OECD 487 /RHE phototoxicity / RHE IL-18 / biotech / Intestinal / small intestine / Intestinal restitution/ Intestinal toxicity / cutaneous / intestinal absorption : intestinal permeability / Apparent permeability / cutaneous absorption OECD TG 428/ systemic / skin / reconstructed tissues / reconstructed epidermises / ocular / metabolism / absorption / permeation / tissue absorption / Tissue Distribution /tissue homogenates / organ / organes / homogenates / h-CLAT OECD 442 E / OCDE 442E / in vitro ADME / DPRA LC MSMS OECD 442 C / Irritation / genotoxicity / microkentine nucleus / micronuclei / , sensitization, sensitisation / 3T3 NRU / OECD/ 3T3 OECD 432/ / OECD 439 skin irritation / OECD 431 skin corrosion / OECD 492 Eye Irritation / OECD 487 micronucleus / DPRA MSMS OECD 442 C / Direct Peptide Reactivity Assay / phototoxicity / method development / method validation / photosensitisation, photosensitization / mass spectrometry / cell culture / permeation intestinal / 3D organotypic human models / complex mixtures / bioanalysis / botanical extracts / hydrophobic materials / microbiota extracts / cytotoxicity / oils / tar / waxes / finished products / chronic exposure / sensitivity / specificity / accuracy / cornea / gingival / buccal / skin metabolism / métabolisme cutané / screening methods / oral absorption / absorption orale / oral distribution / sub-lingual absorption / extrahepatic Metabolism / protein binding / liaison protéique / keratinosens OECD 442D / tissue-Healing / photo-protection / anti inflammation / calming / anti-sensitisation effect / anti-adipogenesis and slimming / pigmentation and whitening / anti-ageing / antipollution / anti-oxidant / permeation enhancement / barrier function and hydratation / matrix composition and synthesis / usb-lingual permeability / cell lines : HO-1-u-1 / 3D human Oral Epithelium models / subcutaneous toxicity / Ames OECD 471 / multiple reconstructed tissues / h-ClaT / hepatic stability / Stabilité hépatique / intestinal stability gastro intestinal aspirates / jejunum aspirates / duodenum aspirates / ileum aspirates / gastric aspirates / gut aspirates / fed - fasted / food effect / microbiota metabolism / anaerobic / fassif / fessif / absorption distribution metabolism excretion / victims perpetrators / Epiintestinal / Skinethic / Mattek / Episkin / Cellsystem / Straticell / RHE IL-18 / Reconstructed human epidermis / Peau humaine reconstruite / Full thickness / vaginal / buccal / oral / performance of oral formulations / gingival / colonic / colon / medium chain fatty acids / derivatisation / pharmacology / absorbed fraction / resorption / keratine / keratinocytes / whole blood /plasma stability / / micro flora / CYP induction / CYP metabolism / UGT / SULT / phenotyping / dose dependant / linearity / plasma binding / RED / equilibrium dialysis / mass spectrometry / qPCR / mRNA / pharmaceutique / quantitative analysis / fluorescence / luminescence / UV / Oroxcell / CRO / Romainville / 93230 / Seine Saint Denis / Parc Biocitech / Biocitech Park / île de France / Caco-2 TC7 cells / lignée de cellules Caco-2 TC7 / In vitro studies and bioanalytical Services since 2004/ Depuis 2004 / From screening to GLP compliant studies / Expert in ADME-toxicology /Toxicologie / Efficacy / Efficacité / Bioanalysis / bioanalyse and 3D-Organotypic Human Model based assay / Modèles 3D humains / Christophe DINI / CEO / Président / Eric ANDRES / Directeur Scientifique Adjoint / Deputy Scientific Director / Rola BARCHAM / Quality Insurance / Responsable de l'assurance qualité / Shakir SHAKIR / Directeur d'études en bioanalyse / Axelle HUYARD / Technicienne en Bioanalyse / Julien GAUTHEROT / Directeur d'étude en études in vitro / Mouctar BARRY / Technicien en études in vitro / Mélissande DINI / Licence for Caco-2 TC7 cells granted from INSERM / LC-MS/MS / RT-qPCR / UV / Fluorescence / Luminescence / ELISA / Analytical support to in vitro / PK and TK studies / Mixtures complexes testées / Complex Mixture testing / Botanical and micorbiota extracts / extraits botaniques / NASH in vitro assay / biomarkers monitoring : Medium Chain Fatty Acids / surveillance des biomarqueurs : Acides gras à chaîne moyenne / GSH depletion / Bile acids accumulation / GLP Grade A / BPL Grade A / AFSSI / ADEBIOTECH / contact@oroxcell.