10x Genomics is a pioneering brand that offers cutting-edge technology in the field of in situ chemistry and transcriptomics. Their innovative products enable the generation of subcellular gene expression maps with exceptional sensitivity and specificity. With their high-performance in situ gene expression technology, 10x Genomics provides a comprehensive solution for researchers in various areas of interest.

One of the standout features of their technology is the use of padlock probe chemistry, making them the only commercial platform to utilize this amplification chemistry. This unique approach allows for high sensitivity across a wide range of expression levels, including low expressing transcripts, and even short or highly degraded transcripts. The tunable sensitivity offered by 10x Genomics also ensures that highly expressed transcripts can be included without compromising performance.

Additionally, their technology allows for the differentiation of transcripts with high homology, such as isoforms. The workflow consists of probe hybridization, ligation, and enzymatic amplification, resulting in a four-step authentication process that ensures the high performance of their technology. The use of gene-specific barcodes generates unique optical signatures for each transcript, enabling accurate identification and spatial mapping of target genes.

Data processing is parallel to the instrument run, allowing for direct exploration of the output. Researchers can sign up for a personalized data demo to explore the power of 10x Genomics' technology in datasets related to human breast cancer or mouse brain. The Xenium In Situ platform offers a complete solution, including the Xenium Analyzer, a user-friendly instrument with fast run times and on-instrument analysis.

Additionally, a range of reagents and panels are available, allowing researchers to customize their experiments to meet their specific research needs. With a dedicated team of spatial experts offering support and expertise, 10x Genomics is committed to assisting researchers throughout their journey. Their products and services have gained recognition in the scientific community, making them a trusted partner for spatial profiling studies.

Overall, 10x Genomics is revolutionizing the field of in situ chemistry and transcriptomics, providing researchers with the tools they need to gain deeper insights into subcellular gene expression. Their cutting-edge technology, combined with personalized support and a user-friendly platform, makes 10x Genomics a leading brand for spatial profiling studies