Apt-Scout

It connects human protein targets with curated aptamer–target binding data and biological context, helping researchers identify proteins with existing reagent evidence and spot potential gaps. The site includes 742 literature-derived affinity measurements across 300 targets and 287 publications. Each measurement is linked to its primary source and exact quoted text, and labelled as intrinsic equilibrium or apparent/avidity data to support more meaningful comparisons. Users can browse, sort, and filter the data, including by aptamer evidence, structure, and other target characteristics.

For 7,177 human protein targets, apt-scout brings together information on structures, modifications, interactions, expression, and disease associations. It also links aptamer affinities to 114 experimental aptamer–protein co-structures, providing evidence about binding sites. Additional views support target exploration for extracellular-vesicle research, while clearly identifying predicted rather than experimentally confirmed accessibility. Tables and data are freely downloadable in CSV and JSON formats, with API access and documentation. apt-scout is designed to inform prioritisation of aptamer, antibody, antisense oligonucleotide, and small-molecule reagents; its scores and predictions are research aids, not experimental measurements.