The Advanced Research Projects Agency for Health (ARPA-H) is a U. S. government agency focused on accelerating transformative advances in health and medicine.

Its mission is to tackle significant health challenges that are too complex, high-risk, or ambitious for traditional research funding and commercial activity, with the goal of delivering breakthroughs in years rather than decades. ARPA-H invests in research spanning fundamental science, translational medicine, and public health, and supports technologies, platforms, capabilities, and solutions with potential for broad impact. Rather than simply funding individual studies, the agency builds research programs, works to remove barriers, and helps accelerate promising innovations toward practical use.

Its portfolio includes initiatives addressing clinical trial speed, personalized autism care, medical imaging, pediatric health data, medicine safety, sleep, and agricultural input management. ARPA-H offers open funding opportunities and resources for applicants, including support for small businesses, and connects researchers and partners through its network and commercialization services