Bio2Byte

Bio2Byte is a research group focused on understanding how protein amino acid sequences relate to biophysical behavior. Based at the Interuniversity Institute of Bioinformatics Brussels and Vrije Universiteit Brussel, the group studies how proteins adopt different conformational states and move between them, rather than treating each protein as a single static structure. Its research combines data integration, analysis, and machine learning to investigate the physical and chemical principles behind protein behavior and connect them to biological events.

Bio2Byte provides online, sequence-based biophysical prediction tools, with a new version in development and a current version retained for compatibility. The website also offers research software and access to data that the group has collected and organized. These resources are intended to support research into protein dynamics, conformational states, and experimental evidence, helping users explore how proteins work. Bio2Byte shares information about its projects, publications, tools, data, and team through its website. Its online prediction infrastructure is hosted on the Flemish Supercomputer Center’s Tier-1 Cloud, supporting prediction services for the research community.