BioSerf

BioSerf, developed by ARIS LLC, provides bioinformatics tools and services for analyzing next-generation sequencing data and discovering genomic biomarkers. Its SERF platform performs de novo genome analysis, helping researchers identify disease and predictive markers, assess immunotherapy response, profile repetitive regions, and explore features such as telomeres and trinucleotide expansions. The site showcases marker analyses spanning human disease, bacteria, SARS-CoV-2, plants, animals, and human chromosomes.

BioSerf offers cloud-enabled and onsite or offsite deployment options, allowing users to analyze genomic datasets on cloud servers or private compute infrastructure. Its web interface supports workflow setup and run monitoring without requiring command-line or Linux expertise, software installation, or local hardware setup. The platform includes tools for sequence alignment, variant and copy-number analysis, mutation calling, quality control, trimming, genome assembly, and consensus analysis, drawing on workflows and utilities such as GATK, STAR, BWA, SAMtools, and Canu. BioSerf also provides services for masking repetitive genomic regions, clustering results, visualizing analyses, and accessing a biomarker database.