Bruker Spatial Genomics

Bruker Spatial Genomics, Inc. develops tools for studying genome organization in individual cells. Its technology enables researchers to directly visualize the three-dimensional genome in situ, examining chromatin structure and chromosome architecture at single-cell and individual-chromosome resolution. The company’s jebFISH technology powers multiplexed genome imaging on the PaintScape platform, helping make detailed analysis of genome organization more accessible.

The PaintScape portfolio includes imaging instruments, assays, and accessories, along with ChromoPaint, PanChromo, and MPX offerings. Researchers can use jebFISH to trace individual chromosome homologs and compare genomic features across cells, including chromatin openness and the proximity of selected regions. Applications described by the company include investigating coding and non-coding regions, cancer driver genes and regulatory regions, chromosome breakpoints, and areas with abnormal ploidy or structure.

Bruker Spatial Genomics positions these capabilities as a way to explore how genome organization relates to cell state, cellular programming, and disease mechanisms. The company also provides scientific resources such as featured data, posters, webinars, events, FAQs, and educational content about the 3D genome.