The Cannabis and Health Research Initiative (CHRI) is a collaborative research platform focused on understanding the patient-level health outcomes of medicinal cannabis use. Developed through a partnership between Johns Hopkins University and Realm of Caring, CHRI brings together experience in cannabis research, data collection, and management. Its work aims to support clinical decision-making, identify opportunities for cannabinoid therapeutics, and inform policy and regulatory decisions in the interest of public and patient health.

CHRI offers several resources for researchers, patients, and others interested in therapeutic cannabis. The National Cannabis Study invites people to share their experiences with medicinal cannabis. Its Data Repository provides access to collected data and research tools, and contributors can submit information to support further study. The Research Library enables users to search scientific articles on cannabis and health. CHRI also provides the Core Assessment Battery for Cannabis, a set of validated questionnaires designed to harmonize research outcomes, and the Cannabis Use Questionnaire, which measures past-month use across retail and prescription cannabis and cannabinoid products.