CLEAR-TB is a global collaboration of experts in tuberculosis research, working to determine the effects of bacterial and host heterogeneity on the manifestations, progression, and consequences of close exposure to TB. The program includes four projects and three cores with the overarching goal of identifying networks in both the host and the Mtb pathogen that govern disease states and treatment responses. Through robust experimental and analytical tools, the team aims to define mechanisms that generate population heterogeneity and drug tolerance, ultimately leading to better and more rapid treatments against TB.

With access to well-characterized clinical TB treatment trials and multi-decade TB household contact studies, CLEAR-TB investigates adaptive changes during Mtb infection and treatment. By utilizing state-of-the-art systems biology approaches, the program aims to identify interactions and network changes that tip the scales of infection either to the bacterium or the host, paving the way for potential therapeutic approaches