Cole DeForest

The DeForest Research Group is a research laboratory focused on advancing biomaterials for applications in human health. Its work brings together rational design, materials science, synthetic chemistry, and stem cell biology to develop next-generation materials for tissue regeneration and disease treatment. The group is particularly interested in user-programmable hydrogels whose biochemical and physical properties can be adjusted across space and over time. Using cell-compatible bioorthogonal chemistries, including reactions activated by light, researchers can modify specific regions of these materials and create dynamic environments that better reflect the changing conditions of native tissue.

The group uses these engineered environments to investigate cell function and to build complex, heterogeneous tissues. Its research areas include programmable biomaterials for guiding stem cell fate, biomolecular and tissue engineering, controlled therapeutic delivery, and tools that enhance proteomic studies. The DeForest Group also shares its work through scientific publications, research highlights, media coverage, and lab resources. Its website features selected and complete publication lists, a cover gallery, photographs, and information about the group’s members and research activities.