SPHINX (Sequence and Phenotype Integration Exchange) is a web-based catalog and research tool developed to help users explore genetic variation and generate hypotheses, particularly about how inherited variants may affect drug response. It brings together data from the eMERGE-PGx and eMERGEseq projects, initiatives of the multi-center eMERGE Network focused on pharmacogenetic sequencing and genomic discovery. The catalog covers 33,966 participants and includes observed variants, genes, and drugs.

Researchers can browse gene and drug lists and search variants by gene, drug interaction, chromosome position, or rsID. Gene pages show observed single nucleotide variants, related drug interactions, and other genes or variants associated with those interactions. Variant records may include rsID, allele frequencies across European, African, and Asian ancestry groups, variant category, and links to resources such as dbSNP and PharmGKB when available. SPHINX provides a searchable way to examine sequencing findings from the network’s targeted assays, supporting investigation of potentially clinically relevant genetic variation and pharmacogenomics.