Escalab, a brand associated with the Escalante Lab at the University of Georgia, is dedicated to advancing our understanding of bacterial and archaeal metabolism and physiology. With a focus on three key areas, Escalab conducts research to unravel complex metabolic pathways, investigate lysine acylation in prokaryotic systems, and explore the metabolic stress caused by toxic metabolites. In the realm of metabolic pathway analysis, Escalab has made significant contributions in the study of the biosynthesis of adenosylcobalamin (AdoCbl), also known as coenzyme B12.

Their research has uncovered new enzymes and pathways in bacteria and archaea, shedding light on the assimilation of incomplete corrinoids and other precursors from the environment. Additionally, the lab has made breakthroughs in understanding the synthesis of specific structural variants of AdoCbl and its association with the cell membrane. Escalab's exploration of lysine acylation in prokaryotic systems aims to understand the physiological roles of this post-translational modification.

By investigating the diverse prokaryotic modifying/de-modifying systems, the brand seeks to uncover the substrates of the modifying enzymes and the effects of their absence or overproduction. The brand's work on the catabolism of acetate and propionate focuses on the molecular basis of their toxicity and the mechanisms used by cells to counteract their harmful effects. Escalab has identified the 2-methylcitric acid cycle as the predominant pathway of propionate catabolism in bacteria, leading to a better understanding of the link between propionate catabolism and glucose auxotrophy.

Through their research, Escalab aims to provide a physiological framework for major biosynthetic pathways, uncover fundamental information about prokaryotic modifying/de-modifying systems, and shed light on the molecular basis of acetate and propionate toxicity. Their work contributes to the advancement of knowledge in the field of microbiology, positioning Escalab as a leading brand in bacterial and archaeal research