The Archicofradía Sacramental de San Roque is a distinguished brotherhood located in Sevilla, Spain, dedicated to the veneration of the Holy Sacrament and various titulars, including Santo Crucifijo de San Agustín and Nuestro Padre Jesús de las Penas. Founded to promote spiritual growth and community service, the brotherhood supports initiatives in formation, charity, and youth engagement. Its activities encompass the celebration of religious events, including rituals, processions, and various acts of worship, such as the annual celebration of the 375th anniversary of the Santo Crucifijo de San Agustín's miracle.

The brotherhood also prioritizes the preservation of its heritage through a wealth of publications, a photo archive, and video content that document its history and cultural significance. Members and interested individuals can participate in numerous religious celebrations, rituals, and gatherings, fostering a deep sense of community and spiritual connection while honoring their religious traditions. Through its ongoing dedication, the Archicofradía continues to be a vital institution within the local community, engaging both the faithful and the broader public.