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IBD-RESPONSE is a UK-wide multi-centre observational cohort study that will develop a predictive algorithm for response or failure to respond to biologic, janus kinase inhibitor (JAKi) and sphingosine-1-phosphate receptor (S1PR) modulator therapies in Crohn's disease and ulcerative colitis.Launched in 2022 our precision medicine research will follow 1,325 patients for the first year after commencing one of these therapies. We will utilise multiple cutting edge technologies to study the gut microbiome, the human genome and immune system integrated with clinical outcome data utilising machine learning techniques.
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IBD-RESPONSE is a pioneering UK-wide multi-centre observational cohort study launched in 2022, dedicated to enhancing treatment strategies for Crohn's disease and ulcerative colitis. The initiative aims to develop a predictive algorithm that assesses patient response to advanced therapies, including biologics, Janus kinase inhibitors (JAKi), and sphingosine-1-phosphate receptor (S1PR) modulators. Over the course of a year, IBD-RESPONSE will monitor 1,325 patients who have started one of these therapies.
Utilizing cutting-edge technologies, the study integrates insights from the gut microbiome, the human genome, and the immune system with clinical outcome data, employing advanced machine learning techniques to refine treatment choices. With participation from 40 clinical centers across the UK, IBD-RESPONSE not only promises to personalize IBD care but also aims to significantly influence clinical practices for the future. This innovative research is crucial in defining predictors of treatment responsiveness and could transform the landscape of IBD management.
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