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IMPORTANT Project IMPlementing geriatric assessment for dose Optimization of CDK 4/6-inhibitors in older bReasT cAncer patieNTs The Vision To design and conduct a pragmatic clinical study with a decentralised approach for older patients (both male and female) with refractory advanced HR+/HER2- negative breast cancer, aiming at high level of evidence (level I) with multi-layer results […]
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The IMPORTANT Project is a European research initiative focused on improving treatment decisions for older people with advanced hormone receptor-positive, HER2-negative breast cancer. Its name stands for “Implementing Geriatric Assessment for Dose Optimization of CDK 4/6-Inhibitors in Older Breast Cancer Patients.” Coordinated by Örebro Läns Landsting, the project brings together partners to study whether vulnerable or frail patients can begin treatment with a lower dose of CDK 4/6 inhibitors alongside endocrine therapy, rather than the recommended full dose.
The project is conducting a multicentre, open-label, prospective, randomized non-inferiority clinical trial using a pragmatic, decentralized approach. Comprehensive geriatric assessment informs evaluation of patients’ frailty before randomization. The study examines prognosis, treatment tolerability and quality of life, while also considering side effects, financial impacts and healthcare costs. Its work includes developing more accessible recruitment methods, supporting shared decisions tailored to individual patients, and preparing a geriatric cancer registry using assessment data and validated quality-of-life questionnaires.
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The IMPORTANT EU Project name, logos and brand assets are trademarks of IMPORTANT EU Project and its affiliates. Brandfetch isn't affiliated with or endorsed by IMPORTANT EU Project. Their use is subject to IMPORTANT EU Project's brand guidelines.
