The Institute of Scientific Instruments of the Czech Academy of Sciences is a research organization based in Brno, Czech Republic. It develops and applies advanced instruments and methods across physics, engineering, materials research, and biomedical science. Its work spans magnetic resonance, electron microscopy and lithography, specialized electronics, laser technology, optical measurement, and spectroscopy. Research examples include laser welding, holographic fiber endoscopy, Raman spectroscopy for biomass identification, diffraction optics, slow-electron microscopy, and optical trapping of nanoparticles. The institute also investigates medical signals, including methods to help identify people at risk of heart failure.

Alongside fundamental research, the institute engages with the application sphere, bringing scientific knowledge and technologies into practical contexts. Its researchers publish findings and participate in international scientific meetings and competitions. The institute also shares its work with the public through media, science festivals, laboratory open days, and a virtual tour. These activities offer visitors opportunities to learn about modern research and see how scientific instruments and technologies are developed and used.