Matthew Macauley

The Macauley Lab, part of the University of Alberta's Department of Chemistry, specializes in interdisciplinary glycoimmunology research, focusing on the intricate relationship between glycans and immune cell function. Utilizing advanced chemical and biochemical techniques, the lab explores how Siglecs, a type of immune receptor, identify and interact with glycan ligands on cells. Their research aims to decipher fundamental biological roles of Siglecs and to develop innovative multivalent probes and chemical tools that manipulate cellular glycans for enhanced immune responses.

The team actively publishes groundbreaking studies, contributing to a deeper understanding of glycoimmunology and its implications in health, including investigations into T cell dynamics and the role of specific glycan interactions in diseases such as Alzheimer's. Emphasizing diversity and collaboration, the lab encourages aspiring researchers to join its mission of advancing immune science through glycochemistry. Overall, the Macauley Lab is dedicated to uncovering the complexities of immune homeostasis and developing novel therapeutic strategies.