Paper Possum is a clinical genetics literature search and evidence workspace designed to help users find, verify, and organize research about genes and variants. The service searches a local literature index and accepts queries in multiple forms, including gene names, variant descriptions, HGVS expressions, rsIDs, ClinVar identifiers, PMIDs, and DOIs. When a variant is resolved, the workspace can display canonical nomenclature, transcript, genome build, aliases, and related disease or case context when supplied.

Paper Possum draws on sources including PubMed, Europe PMC, PMC full text, PubTator, and supplemental-file candidates. It ranks papers by relevance and helps users inspect variant mentions in their source context, including full-text and supplemental material where available. Users can review evidence, apply include, exclude, or defer decisions, and retain review choices in their browser for a query and disease context. The platform emphasizes source provenance while clarifying that relevance rankings are not ACMG/AMP evidence-strength assessments. Paper Possum also offers information about its approach, pilot and pricing, account creation, and contact options.