Penelope is a contemporary American café and wine bar in Manhattan’s Murray Hill, located at 159 Lexington Avenue. Celebrating its place in the neighborhood since 2003, the restaurant offers a welcoming setting that shifts from an all-day café to an intimate evening wine bar. Its menu features comfort food and a range of dishes, including burgers, sandwiches, seafood, salads, brunch favorites, and gluten-free options. The café also serves locally roasted coffee, while its drinks program includes craft cocktails and an extensive selection of wines, with old-world and natural wines chosen to complement the food. Afternoon Social Hour offers special pricing on food and wine.

Penelope supports farm-to-table cooking by sourcing fresh ingredients from local farmers. Guests can order online, dine in, or arrange catering for occasions ranging from small gatherings to weddings and corporate events. The restaurant also hosts private parties, office functions, showers, anniversaries, family reunions, and other celebrations, offering event-planning support and packages designed with budgets in mind.