USA Prime Puff is an online retailer offering a broad selection of vaping products, e-liquids, and related accessories. Its catalog includes disposable vapes and prefilled pod kits from brands such as Lost Mary, Flavour Beast, and IVG, alongside replacement pods and vape devices. Customers can also browse e-liquids and salt nicotine options in a range of named flavors, including fruit, menthol, and candy-inspired varieties.

Beyond vaping, USA Prime Puff lists smoking and lifestyle accessories, including grinders, rolling trays, bubblers, cleaning products, and cigar essentials. The cigar selection includes Montecristo cigars, while accessories include humidors. Apparel, such as branded T-shirts, is also featured. The store organizes its inventory across categories including e-liquid, e-juice, disposables, and vape juices, with products available to add to an online cart. Its website provides information about the company, contact details, order tracking, shipping and returns, and privacy and terms policies. USA Prime Puff advertises free shipping on orders over $50 and lists a New York City address and an email contact for customer inquiries.