Mark Cuban Companies is a portfolio and business platform showcasing a diverse range of ventures associated with Mark Cuban. Its companies span industries including healthcare and biotech, artificial intelligence, consumer products, food, media, sports, blockchain, productivity, and social and civic initiatives. The portfolio features businesses offering practical products and technology-driven services, from low-cost generic medicines through Mark Cuban Cost Plus Drug Company to affordable furnished rooms through PadSplit and student moving and storage through Storage Scholars. Other offerings include independent film distribution, live-event production, sports apparel, plant-based foods, beauty and hair-care products, and tools for healthcare providers and communications teams.

The portfolio also includes technology companies developing AI platforms, analytics software, digital media tools, blockchain applications, and systems for industries such as construction, athletics, and healthcare. Alongside commercial ventures, the wider organization highlights the Mark Cuban Foundation, which supports communities and nonprofit organizations, and the Mavs Foundation, which serves youth, women, families, and communities in need.