The National Mississippi River Museum & Aquarium, operated by the Dubuque County Historical Society, is dedicated to interpreting the rich history and significance of the Mississippi River and the Dubuque region. The main campus, consisting of the Diamond Jo National River Center, Fred W. Woodward Freight House, and the William Woodward Mississippi River Center, offers engaging exhibits and educational experiences that bring to life the stories of natural science and human innovation shaped by the region's inland waterways.

The museum's mission is to inspire stewardship through educational experiences that showcase the history and significance of rivers. It is committed to embracing diversity, practicing equity, and ensuring accessibility and inclusion in all aspects of its operations.

Visitors can enjoy a wide range of exciting experiences, including up-close encounters with marine life at the Tidepool Touch Tank, conservation efforts to save endangered species, and a rich collection of 26,000 artifacts that tell the compelling stories of the region's history. The museum also offers various educational programs and outreach initiatives for youth to learn about history, culture, and STEM-related topics. With initiatives aimed at environmental conservation and historic preservation, the museum serves as a hub for creating awareness and promoting a deeper understanding of the region's natural and cultural heritage.

The National Mississippi River Museum & Aquarium offers membership and support opportunities that provide exclusive benefits and help inspire stewardship of our rivers and history for individuals and families from around the world. Every admission ticket is a two-day pass, providing access to the museum's captivating blend of museum, aquarium, and science center. Whether through donations, membership, or advocacy, there are numerous ways to contribute to the museum's mission-driven educational experiences, conservation efforts, and historic preservation.