RxDiff is a free prescription price comparison service that helps people check estimated medication prices at nearby pharmacies before filling a prescription. Users can search without creating an account or having insurance, and compare options across CVS, Walgreens, Walmart, Kroger, and more than 70,000 pharmacies. The site covers over 3,500 medications, with prices tailored to the medication and ZIP code; displayed amounts are estimates and may vary by location and pharmacy.

Alongside its price search, RxDiff provides medication information and practical resources for making informed savings choices. Its tools include a pill identifier, drug interaction information, manufacturer coupons, and medication price guides. Articles explain how prescription discount cards work, how to compare offers, and how discounts may differ from insurance copays. RxDiff also publishes comparisons with other prescription savings services and guides covering topics such as 90-day supplies and pharmacy price differences. The company states that it is not a pharmacy or healthcare provider.