Santa Casa da Misericórdia de Alfândega da Fé is a Portuguese charitable institution serving the community of Alfândega da Fé. Its work spans social care, health-related services, religious activities, and community support. The organisation operates residential care homes for older people, including ERPI Nossa Senhora das Dores, ERPI de Vilarelhos, and ERPI de Vilarchão. It also provides a day centre in Vilarchão, home support, preschool education, and nursery care.

Its other services include physical medicine and rehabilitation, a social canteen, a medical post, funeral services, weekly Masses, and religious activities. The institution also offers administrative and supply services and lists social housing rentals among its activities. Its website shares information about its history, mission, values, partnerships, governance, facilities, news, and donation options. The Santa Casa is located on Avenida Sá Carneiro in Alfândega da Fé and can be contacted by telephone or email. Through its range of care and community services, it supports people and families across different stages and circumstances of life.