Santa Casa da Misericórdia de Odemira is a Portuguese private social solidarity institution serving the community of Odemira and Colos. Guided by humanist principles and Christian doctrine, it supports people in need and promotes the traditional Corporal and Spiritual Works of Mercy. The institution describes itself as a local development and social-economy partner, working to support families, strengthen community cohesion, encourage social inclusion, and help address rural depopulation.

Its services include residential care for older people at Lar Nossa Senhora da Visitação in Odemira and Casa de Repouso de Santo António in Colos, which has cooperation agreements for 41 residents. It also provides home support in Odemira and Colos, a social canteen under the Emergency Food Programme, and continuing integrated care through its health services. Additional initiatives include the Saúde no Mira mobile health unit, the Viver Melhor health-services project, and the Afectos programme for older people. The institution also offers volunteer opportunities through the Dar Sentido project and welcomes donations to support its work.