Skullgirls is a fighting game brand centered on stylish, hand-drawn 2D action and competitive battles. Its games combine distinctive characters, fast-paced combat, and a strong emphasis on learning and mastering moves and combos. Skullgirls Mobile expands the experience with role-playing progression, allowing players to collect, customize, level up, and evolve fighters as they search for the mysterious Skullgirl.

Players can equip and upgrade special moves and Blockbusters, then assemble teams of up to three characters to develop effective strategies and synergies. Mobile controls support quick actions through taps and swipes, while Fight Assist helps newcomers focus on tactical choices; experienced players can explore deeper combat techniques, including combos and juggles. The game offers story missions, daily character events, prize fights, real-time online versus battles, and Rift Battles, where players build defenses and challenge others for rewards.

Guild events add cooperative quests and boss battles. The Skullgirls website also provides news, a store, gear, a wiki, and player support resources. The brand is associated with Autumn Games LLC