St. Louis Art Supply is an independent, artist-owned art supply store founded in 2015. Based in St. Louis, Missouri, it serves local customers through its neighborhood shop and ships fine art materials to customers across the United States. The company describes itself as a small, passionate team focused on offering carefully selected supplies beyond mass-market basics, with real people available to answer questions.

Its catalog supports painting, drawing, writing, and calligraphy, alongside crafts and creative studio work. Products include watercolor, acrylic and oil paints; brushes, canvases and other surfaces; paper, sketchbooks and notebooks; pencils, pens, inks, markers and pastels; and printmaking, bookbinding, sewing, embroidery and knitting materials. The store also sells art instruction and history books, design titles, literature, tools, storage, and gifts.

St. Louis Art Supply produces its own Federal Color line, including paper goods and Tonic Watercolor, made at its St. Louis headquarters. It also imports selected products from Japan and Europe and carries brands such as Daniel Smith, Hahnemühle, Kakimori, Kuretake and Royal Talens.