SynerFuse is a medical technology company focused on addressing chronic lower back and leg pain in patients undergoing spinal fusion. Its featured offering is the SynerFuse e-TLIF procedure, described as a ULE (Ultra Low Energy) therapy intended for use in this patient population. The company presents the approach as an integrated solution designed to support better outcomes and improved lives, and its website highlights clinical research alongside information about its technology, leadership, and investors.

SynerFuse frames its work against the significant burden of chronic back pain, spinal surgery, and opioid use in the United States. The figures presented on its website describe the scale of these challenges, including ongoing pain among some spinal fusion patients. The e-TLIF is an investigational device, and the company cautions that it is limited by federal law to investigational use; it should not be understood as an established or generally available treatment. Based in Eden Prairie, Minnesota, SynerFuse shares information about its technology and research with patients, clinicians, and other interested audiences.