Translucence Biosystems

Translucence Biosystems develops tools and services that help researchers and clinicians study the three-dimensional structure and activity of biological samples. Its work supports a shift from traditional two-dimensional histology to comprehensive 3D analysis, combining tissue clearing and staining, light-sheet imaging, computational reconstruction, and machine-learning-based quantification.

The company’s products include Universal, Neuronal Activity, and Neuroinflammation Tissue Clearing Kits, designed for a range of tissues and research applications. Its Mesoscale Imaging System adapts ZEISS Lightsheet Z.1 and Lightsheet 7 microscopes for imaging large, cleared samples, while Stitchy streamlines the stitching of large 3D image datasets.

Translucence also offers custom and full-pipeline services, including tissue clearing, high-resolution imaging, image stitching, and AI-powered quantification. Research applications include brain-wide studies of Alzheimer’s and Parkinson’s disease, neuroinflammation, neuronal activity, and therapeutic antibody distribution, as well as 3D visualization of liver bile ducts and organ vasculature. By bringing sample preparation, imaging, and analysis together, Translucence Biosystems aims to make reliable 3D histology workflows more accessible and efficient.