Triple Helical Peptides Ltd
@triplehelical.com
The human collagens are a family of 28 triple-helical proteins forming vertebrates' most abundant protein group. Their defining Gly-X-Y repeating sequence confers triple-helical structure on the collagens. Far from inert, collagens must offer specific interaction sites for other matrix components. Evolutionarily formed signatures within the primary GXY sequence of collagen enable it to play roles in cell anchoring, survival, and function that are fundamental to the integrity of the extracellular matrix. Here at Triple Helical Peptides Ltd, we design and synthesize triple-helical peptides designed to further our understanding of the interactions of collagens with the cells and proteins on which we all depend.
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About Triple Helical Peptides Ltd
Triple Helical Peptides is a specialist supplier of collagen-like peptides, synthesising and distributing triple-helical peptides primarily for research use. Its products reproduce the structure and selected binding properties of collagen, enabling researchers to study interactions between collagen and proteins or cells. Peptide activity depends on both the amino acid sequence and its triple-helical conformation; linear versions are also available as control materials.
The range includes ligands for Glycoprotein VI (GPVI), collagen-binding integrins such as α1β1, α2β1, α10β1 and α11β1, and the A3 domain of von Willebrand factor. These reagents support platelet activation and adhesion research, including aggregation assays, washed platelet studies, plate coatings and experiments involving flowing blood. The company also offers the Collagen Ligands Collection, formerly known as the Collagen Toolkits: overlapping peptides used to map binding sites and identify specific collagen-recognition motifs. These ligands can help researchers investigate target interactions and develop materials for structural studies or high-throughput screening. Triple Helical Peptides Ltd is registered in England and Wales.
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