WebMO is a web-based interface that helps students, researchers, and other users run computational chemistry programs through a browser. Designed to serve both newcomers and experienced users, it offers a point-and-click 3-D molecular editor, predefined job types, and sensible defaults, alongside advanced settings and direct access to input and output files. WebMO supports a range of popular chemistry engines, including Gaussian, GAMESS, ORCA, NWChem, Q-Chem, and TeraChem, and can display results such as molecular orbitals, electrostatic potentials, molecular vibrations, infrared spectra, and NMR spectra.

The product is available in several versions. WebMO Basic is free and includes core editing, program interfaces, and graphical results. WebMO Pro adds calculation, visualization, and job-management capabilities, while Enterprise extends Pro for larger user groups and computer clusters. WebMO Cloud provides a pre-installed Enterprise service, so users can run jobs without maintaining a local server. A free mobile app for iOS and Android supports local calculations, chemical-information lookup, and WebMO job submission and viewing.